The purpose of present study was to develop quality based formulation of gelrite based ophthalmic in-situ gel of olopatadine hydrochloride using HPMC E15LV polymer. The in-situ forming gel was prepared by using different concentration of gelrite. The effects of various experimental parameters were optimized by means of experimental 32 designs. Formulations were evaluated for their pH, clarity, gelation studies, viscosity, mucoadhesion index, gel strength and in-vitro drug release. Olopatadine hydrochloride containing gelrite, HPMC K15LV exhibited non-newtonian flow behavior. pH, clarity and gelation studies were found in acceptable range. From 32 optimization, gelrite was found to have significant effect on mucoadhesion index. Gelrite showed a positive effect on gel strength. HPMC K15LV was also helpful in controlling the release rate of drug. Optimized batch (F9) containing 0.5% gelrite 0.3% HPMC K15LV was exhibited all tests in acceptable limits.
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